| First Author | Shin MK | Year | 1999 |
| Journal | Nature | Volume | 402 |
| Issue | 6761 | Pages | 496-501 |
| PubMed ID | 10591209 | Mgi Jnum | J:58698 |
| Mgi Id | MGI:1349495 | Doi | 10.1038/990040 |
| Citation | Shin MK, et al. (1999) The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature 402(6761):496-501 |
| abstractText | Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons. Mice that are homozygous for a null mutation in the Ednrb gene are almost completely white and die as juveniles from megacolon. To determine when EDNRB signalling is required during embryogenesis, we have exploited the tetracycline-inducible system to generate strains of mice in which the endogenous Ednrb locus is under the control of the tetracycline-dependant transactivators tTa or rtTA. By using this system to express Ednrb at different stages of embryogenesis, we have determined that EDNRB is required during a restricted period of neural crest development between embryonic days 10 and 12.5. Moreover, our results imply that EDNRB is required for the migration of both melanoblasts and enteric neuroblasts. |
