| First Author | Degg NL | Year | 2003 |
| Journal | Cancer Res | Volume | 63 |
| Issue | 10 | Pages | 2361-3 |
| PubMed ID | 12750251 | Mgi Jnum | J:83497 |
| Mgi Id | MGI:2662094 | Citation | Degg NL, et al. (2003) Adenoma multiplicity in irradiated apc(min) mice is modified by chromosome 16 segments from BALB/c. Cancer Res 63(10):2361-3 |
| abstractText | Ionizing radiation (IR) is a well-characterized carcinogen in humans and mice. The BALB/c mouse strain is unusually sensitive to IR-induced tissue damage and cancer development in a range of organs, suggestive of a partial defect in DNA damage response. This has been confirmed by finding BALB/c-specific functional polymorphism in Prkdc, a gene on mouse chromosome 16 that encodes the catalytic subunit of DNA-dependent protein kinase. Prkdc(BALB) has been associated with increased susceptibility to IR-induced mammary and lymphatic neoplasia. Here, we provide evidence that chromosome 16 segments from BALB/c interact with Apc(Min) (multiple intestinal neoplasia) and specifically enhance IR-induced adenoma development in the upper part of the small intestine. |
