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Allele : Pik3ca<tm1Gilb> phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Richard Gilbertson
Primary Identifier  MGI:5438138 Allele Type  Targeted
Attribute String  Conditional ready, No functional change Gene  Pik3ca
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A floxed puro/STOP cassette was inserted upstream of the exon containing the initiation codon. Exon 9 was replaced with one in which nucleotide substitution results in the amino acid substitution of lysine for glutamic acid at position 545 (E545K). Flp-mediated recombination removed the floxed neo cassette inserted into intron 9. Cre-mediated recombination is required to achieve expression of the knock-in allele.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • Pik3ca<loxE545K>,
  • Pik3ca<loxE545K>,
  • Pik3ca<E545K>,
  • Pik3ca<E545K>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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0 Driven By

12 Publication categories

Trail: Allele




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