| First Author | Serikov VB | Year | 2001 |
| Journal | Circ Res | Volume | 88 |
| Issue | 1 | Pages | 9-11 |
| PubMed ID | 11139467 | Mgi Jnum | J:115594 |
| Mgi Id | MGI:3691974 | Doi | 10.1161/01.res.88.1.9 |
| Citation | Serikov VB, et al. (2001) Reduction of [Ca(2+)](i) restores uncoupled beta-adrenergic signaling in isolated perfused transgenic mouse hearts. Circ Res 88(1):9-11 |
| abstractText | The effects of alterations in calcium in the perfusion media were studied on ss-adrenergic coupling in isolated hearts from 3 different transgenic mice: cardiac-specific overexpressed alpha(1) subunit of L-type calcium channel, overexpressed Galpha(q), and phospholamban knockout. Isolated hearts from all 3 models, when studied at [Ca(2+)] of 2 mmol/L in the perfusate, showed the usual blunted or no response to ss-adrenergic stimulation. Lowering [Ca(2+)] to 0.75 to 1.5 mmol/L unloaded the hearts of calcium and restored to nearly normal the responsiveness to ss-agonist stimulation. |
