| First Author | Hasebe R | Year | 2014 |
| Journal | Biochem Biophys Res Commun | Volume | 454 |
| Issue | 1 | Pages | 125-30 |
| PubMed ID | 25450368 | Mgi Jnum | J:220281 |
| Mgi Id | MGI:5634065 | Doi | 10.1016/j.bbrc.2014.10.043 |
| Citation | Hasebe R, et al. (2014) Temporary upregulation of anti-inflammatory cytokine IL-13 expression in the brains of CD14 deficient mice in the early stage of prion infection. Biochem Biophys Res Commun 454(1):125-30 |
| abstractText | CD14 deficient (CD14(-/-)) mice survived longer than wild-type (WT) C57BL/6J mice when inoculated with prions intracerebrally, accompanied by increased expression of anti-inflammatory cytokine IL-10 by microglia in the early stage of infection. To assess the immune regulatory effects of CD14 in detail, we compared the gene expression of pro- and anti-inflammatory cytokines in the brains of WT and CD14(-/-) mice infected with the Chandler strain. Gene expression of the anti-inflammatory cytokine IL-13 in prion-infected CD14(-/-) mice was temporarily upregulated at 75dpi, whereas IL-13 gene expression was not upregulated in prion-infected WT mice. Immunofluorescence staining showed that IL-13 was mainly expressed in neurons of the thalamus at 75dpi. These results suggest that CD14 can suppress IL-13 expression in neurons during the early stage of prion infection. |
