| First Author | Dehn AS | Year | 2023 |
| Journal | J Cell Sci | Volume | 136 |
| Issue | 20 | PubMed ID | 37732459 |
| Mgi Jnum | J:343674 | Mgi Id | MGI:7565982 |
| Doi | 10.1242/jcs.260974 | Citation | Dehn AS, et al. (2023) Epithelial mechanics are maintained by inhibiting cell fusion with age in Drosophila. J Cell Sci 136(20) |
| abstractText | A characteristic of normal aging and age-related diseases is the remodeling of the cellular organization of a tissue through polyploid cell growth. Polyploidy arises from an increase in nuclear ploidy or the number of nuclei per cell. However, it is not known whether age-induced polyploidy is an adaption to stressors or a precursor to degeneration. Here, we find that abdominal epithelium of the adult fruit fly becomes polyploid with age through generation of multinucleated cells by cell fusion. Inhibition of fusion does not improve the lifespan of the fly, but does enhance its biomechanical fitness, a measure of the healthspan of the animal. Remarkably, Drosophila can maintain their epithelial tension and abdominal movements with age when cell fusion is inhibited. Epithelial cell fusion also appears to be dependent on a mechanical cue, as knockdown of Rho kinase, E-cadherin or alpha-catenin is sufficient to induce multinucleation in young animals. Interestingly, mutations in alpha-catenin in mice result in retina pigment epithelial multinucleation associated with macular disease. Therefore, we have discovered that polyploid cells arise by cell fusion and contribute to the decline in the biomechanical fitness of the animal with age. |
