| First Author | Tsai JJ | Year | 2013 |
| Journal | Nat Cell Biol | Volume | 15 |
| Issue | 3 | Pages | 309-16 |
| PubMed ID | 23434824 | Mgi Jnum | J:195199 |
| Mgi Id | MGI:5476857 | Doi | 10.1038/ncb2699 |
| Citation | Tsai JJ, et al. (2013) Nrf2 regulates haematopoietic stem cell function. Nat Cell Biol 15(3):309-16 |
| abstractText | Coordinating the balance between haematopoietic stem cell (HSC) quiescence and self-renewal is crucial for maintaining haematopoiesis lifelong. Equally important for haematopoietic function is modulating HSC localization within the bone marrow niches, as maintenance of HSC function is tightly controlled by a complex network of intrinsic molecular mechanisms and extrinsic signalling interactions with their surrounding microenvironment. In this study we demonstrate that nuclear factor erythroid 2-related factor 2 (Nfe2l2, or Nrf2), well established as a global regulator of the oxidative stress response, plays a regulatory role in several aspects of HSC homeostasis. Nrf2 deficiency results in an expansion of the haematopoietic stem and progenitor cell compartment due to cell-intrinsic hyperproliferation, which was accomplished at the expense of HSC quiescence and self-renewal. We further show that Nrf2 modulates both migration and retention of HSCs in their niche. Moreover, we identify a previously unrecognized link between Nrf2 and CXCR4, contributing, at least partially, to the maintenance of HSC function. |
