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Allele : Foxn1<em1Dvs> forkhead box N1; endonuclease-mediated mutation 1, David V Serreze
Primary Identifier  MGI:5882743 Allele Type  Endonuclease-mediated
Attribute String  Null/knockout Gene  Foxn1
Strain of Origin  NOD.Cg-Prkdc<scid> Il2rg<tm1Wjl>/SzJ Is Recombinase  false
Is Wild Type  false
molecularNote  CRISPR/cas9 endonuclease mediated genome editing is used to introduce a 1 nucleotide deletion (GGCcAACGCCG to GGC-AACGCCG) in exon 5 (encodes the N-terminal portion of the DNA binding domain). This 1 nucleotide deletion causes a frame shift and premature truncation after an additional out-of-frame ~120 nucleotides - resulting in a 300 aa protein.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • Foxn1<null>,
  • Foxn1<null>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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