| First Author | Sarute N | Year | 2020 |
| Journal | Proc Natl Acad Sci U S A | Volume | 117 |
| Issue | 32 | Pages | 19497-19506 |
| PubMed ID | 32719120 | Mgi Jnum | J:294190 |
| Mgi Id | MGI:6450975 | Doi | 10.1073/pnas.1920551117 |
| Citation | Sarute N, et al. (2020) CACNA1S haploinsufficiency confers resistance to New World arenavirus infection. Proc Natl Acad Sci U S A 117(32):19497-19506 |
| abstractText | Understanding the genetics of susceptibility to infectious agents is of great importance to our ability to combat disease. Here, we show that voltage-gated calcium channels (VGCCs) are critical for cellular binding and entry of the New World arenaviruses Junin and Tacaribe virus, suggesting that zoonosis via these receptors could occur. Moreover, we demonstrate that alpha1s haploinsufficiency renders cells and mice more resistant to infection by these viruses. In addition to being more resistant to infection, haploinsufficient cells and mice required a lower dosage of VGCC antagonists to block infection. These studies underscore the importance of genetic variation in susceptibility to both viruses and pharmaceutics. |
