| First Author | Hörig H | Year | 2001 |
| Journal | Cancer Res | Volume | 61 |
| Issue | 23 | Pages | 8520-6 |
| PubMed ID | 11731437 | Mgi Jnum | J:73156 |
| Mgi Id | MGI:2154633 | Citation | Horig H, et al. (2001) A new mouse model for evaluating the immunotherapy of human colorectal cancer. Cancer Res 61(23):8520-6 |
| abstractText | A new murine model of human colorectal cancer was generated by crossing human carcinoembryonic antigen (CEA) transgenic mice (H-2K(b)) with adenomatous polyposis coli (Apc1638N) knockout mice (H-2K(b)). The resulting hybrid mice developed gastrointestinal polyps in 6-8 months that progressed to invasive carcinomas with a similar pattern of dysplasia and CEA expression as observed in human colorectal cancer. These animals exhibited incomplete or partial tolerance to CEA as evidenced by delayed growth of CEA-expressing tumors and the inability to inhibit CEA-specific CTL responses. These results have important implications for understanding the role of CEA-specific immunity in human colon cancer patients and suggest that vaccine strategies targeting CEA may be feasible. This model provides a powerful system for evaluating antigen-specific tumor immunity against spontaneous tumors arising in an orthotopic location and permits evaluation of therapeutic vaccine strategies for human colorectal cancer. |
