Primary Identifier | MGI:6111819 | Allele Type | Targeted |
Attribute String | Not Specified | Gene | Tbc1d4 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The 917 codon (according to NP_001074747.2, and equivalent to Arg973 on human AS160) was mutated to express a lysine residue instead of arginine in order to inactivate the GAP function of the encoded protein. A loxP-flanked neomycin selection cassette that was placed next to the mutated exon was removed in the final allele. |