| Primary Identifier | MGI:3695884 | Allele Type | Transgenic |
| Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Tg(SOD1*H46R*H48Q)58Dbo |
| Strain of Origin | (C3H/HeJ x C57BL/6J)F2 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A 12kb genomic fragment containing the entire human SOD1 gene was mutated so that the histidine residue at position 46 was replaced by arginine and the histidine at position 48 was replaced by glutamine in the encoded protein. This line is the representative line of 10 that developed motor neuron disease before 1 year of age. Lines 73, 67, and 58 show identical pathological changes. |
