| First Author | Tano K | Year | 2010 |
| Journal | Drug Discov Ther | Volume | 4 |
| Issue | 5 | Pages | 368-72 |
| PubMed ID | 22491241 | Mgi Jnum | J:258002 |
| Mgi Id | MGI:6144042 | Citation | Tano K, et al. (2010) Reduced expression of Sytl 1 and Ccdc21 and impaired induction of Mt I by oxidative stress in SII-K1 knockout mice. Drug Discov Ther 4(5):368-72 |
| abstractText | SII-K1 is a member of the transcription elongation factor S-II family. In the mouse, SII-K1 is expressed exclusively in the liver, kidney, heart, and skeletal muscle. Here, we report that deletion of the SII-K1 gene in mice resulted in the downregulation of the synaptotagmin-like 1 (Sytl 1) gene in liver and of the coiled-coil domain-containing 21 (Ccdc21) gene in liver and kidney. Moreover, the induction of the metallothionein I (Mt I) gene in SII-K1-deficient mice liver was impaired in diethyl maleate-induced oxidative stress conditions. Our results suggest that SII-K1 regulates these genes in vivo. |
