| First Author | Matsushita H | Year | 2010 |
| Journal | Neurosci Res | Volume | 68 |
| Issue | 2 | Pages | 151-3 |
| PubMed ID | 20600375 | Mgi Jnum | J:262922 |
| Mgi Id | MGI:6187765 | Doi | 10.1016/j.neures.2010.06.007 |
| Citation | Matsushita H, et al. (2010) Oxytocin mediates the antidepressant effects of mating behavior in male mice. Neurosci Res 68(2):151-3 |
| abstractText | A significant association between plasma oxytocin (OT) levels and depression has been demonstrated. A recent study found that sexual activity and mating with a female induced the release of OT in the central nervous system of male rats. Here we examined the effect of mating behavior on depression-related behavior in wild-type (WT) and OT receptor-deficient (OTR KO) male mice. The WT males showed a reduction in depression-related behavior after mating behavior, but the OTR KO mice did not. Application of an OTR antagonist inhibited mating behavior-induced antidepressant effect in WT males. OT may mediate the antidepressant effects of mating behavior. |
