| First Author | Requejo-Aguilar R | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 4514 | PubMed ID | 25058378 |
| Mgi Jnum | J:330134 | Mgi Id | MGI:7365312 |
| Doi | 10.1038/ncomms5514 | Citation | Requejo-Aguilar R, et al. (2014) PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1. Nat Commun 5:4514 |
| abstractText | PTEN-induced kinase-1 (PINK1) is a Ser/Thr kinase implicated in familial early-onset Parkinson's disease, and was first reported as a growth suppressor. PINK1 loss-of-function compromises both mitochondrial autophagy and oxidative phosphorylation. Here we report that PINK1 deficiency triggers hypoxia-inducible factor-1alpha (HIF1alpha) stabilization in cultured Pink1(-/-) mouse embryonic fibroblasts and primary cortical neurons as well as in vivo. This effect, mediated by mitochondrial reactive oxygen species, led to the upregulation of the HIF1 target, pyruvate dehydrogenase kinase-1, which inhibits PDH activity. Furthermore, we show that HIF1alpha stimulates glycolysis in the absence of Pink1, and that the promotion of intracellular glucose metabolism by HIF1alpha stabilization is required for cell proliferation in Pink1(-/-) mice. We propose that loss of Pink1 reprograms glucose metabolism through HIF1alpha, sustaining increased cell proliferation. |
