| First Author | Ueki Y | Year | 2012 |
| Journal | Glia | Volume | 60 |
| Issue | 10 | Pages | 1579-89 |
| PubMed ID | 22777914 | Mgi Jnum | J:186483 |
| Mgi Id | MGI:5432428 | Doi | 10.1002/glia.22377 |
| Citation | Ueki Y, et al. (2012) P53 is required for the developmental restriction in Muller glial proliferation in mouse retina. Glia 60(10):1579-89 |
| abstractText | Muller glia are normally mitotically quiescent cells, but in certain pathological states they can re-enter the mitotic cell cycle. While several cell cycle regulators have been shown to be important in this process, a role for the tumor suppressor, p53, has not been demonstrated. Here, we investigated a role for p53 in limiting the ability of Muller glia to proliferate in the mature mouse retina. Our data demonstrate that Muller glia undergo a developmental restriction in their potential to proliferate. Retinal explants or dissociated cultures treated with EGF become mitotically quiescent by the end of the second postnatal week. In contrast, Muller glia from adult trp53-/+ or trp53-/- mice displayed a greater ability to proliferate in response to EGF stimulation in vitro. The enhanced proliferative ability of trp53 deficient mice correlates with a decreased expression of the mitotic inhibitor Cdkn1a/p21(cip) and an increase in c-myc, a transcription factor that promotes cell cycle progression. These data show that p53 plays an essential role in limiting the potential of Muller glia to re-enter the mitotic cycle as the retina matures during postnatal development. (c) 2012 Wiley Periodicals, Inc. |
