| First Author | Rohani MG | Year | 2015 |
| Journal | J Invest Dermatol | Volume | 135 |
| Issue | 10 | Pages | 2377-2384 |
| PubMed ID | 25927164 | Mgi Jnum | J:226006 |
| Mgi Id | MGI:5695436 | Doi | 10.1038/jid.2015.167 |
| Citation | Rohani MG, et al. (2015) MMP-10 Regulates Collagenolytic Activity of Alternatively Activated Resident Macrophages. J Invest Dermatol 135(10):2377-84 |
| abstractText | Matrix metalloproteinase-10 (MMP-10) is expressed by macrophages and epithelium in response to injury, but its functions in wound repair are unknown. We observed increased collagen deposition and skin stiffness in Mmp10(-/-) wounds, with no difference in collagen expression or reepithelialization. Increased collagen deposition in Mmp10(-/-) wounds was accompanied by less collagenolytic activity and reduced expression of specific metallocollagenases, particularly MMP-8 and MMP-13, where MMP-13 was the key collagenase. Ablation and adoptive transfer approaches and cell-based models demonstrated that the MMP-10-dependent collagenolytic activity was a product of alternatively activated (M2) resident macrophages. These data demonstrate a critical role for macrophage MMP-10 in controlling the tissue remodeling activity of macrophages and moderating scar formation during wound repair. |
