| First Author | Lee CS | Year | 2016 |
| Journal | BMB Rep | Volume | 49 |
| Issue | 3 | Pages | 191-6 |
| PubMed ID | 26818087 | Mgi Jnum | J:231467 |
| Mgi Id | MGI:5771608 | Doi | 10.5483/bmbrep.2016.49.3.219 |
| Citation | Lee CS, et al. (2016) Loss of phospholipase D2 impairs VEGF-induced angiogenesis. BMB Rep 49(3):191-6 |
| abstractText | Vascular endothelial growth factor (VEGF) is a key mediator of angiogenesis and critical for normal embryonic development and repair of pathophysiological conditions in adults. Although phospholipase D (PLD) activity has been implicated in angiogenic processes, its role in VEGF signaling during angiogenesis in mammals is unclear. Here, we found that silencing of PLD2 by siRNA blocked VEGF-mediated signaling in immortalized human umbilical vein endothelial cells (iHUVECs). Also, VEGF-induced endothelial cell survival, proliferation, migration, and tube formation were inhibited by PLD2 silencing. Furthermore, while Pld2-knockout mice exhibited normal development, loss of PLD2 inhibited VEGF-mediated ex vivo angiogenesis. These findings suggest that PLD2 functions as a key mediator in the VEGF-mediated angiogenic functions of endothelial cells. [BMB Reports 2016; 49(3): 191-196]. |
