| First Author | Scott EW | Year | 1994 |
| Journal | Science | Volume | 265 |
| Issue | 5178 | Pages | 1573-7 |
| PubMed ID | 8079170 | Mgi Jnum | J:20348 |
| Mgi Id | MGI:68444 | Doi | 10.1126/science.8079170 |
| Citation | Scott EW, et al. (1994) Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265(5178):1573-7 |
| abstractText | The transcription factor PU.1 is a hematopoietic-specific member of the ets family. Mice carrying a mutation in the PU.1 locus were generated by gene targeting. Homozygous mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers of megakaryocytes and erythroid progenitors, but some showed an impairment of erythroblast maturation. An invariant consequence of the mutation was a multilineage defect in the generation of progenitors for B and T lymphocytes, monocytes, and granulocytes. Thus, the developmental programs of lymphoid and myeloid lineages require a common genetic function likely acting at the level of a multipotential progenitor. |
