| First Author | Kyuwa S | Year | 1998 |
| Journal | J Virol | Volume | 72 |
| Issue | 11 | Pages | 9286-90 |
| PubMed ID | 9765476 | Mgi Jnum | J:50405 |
| Mgi Id | MGI:1303269 | Doi | 10.1128/jvi.72.11.9286-9290.1998 |
| Citation | Kyuwa S, et al. (1998) Murine coronavirus-induced subacute fatal peritonitis in C57BL/6 mice deficient in gamma interferon. J Virol 72(11):9286-90 |
| abstractText | Gamma interferon-deficient (IFN-gamma-/-) mice with a C57BL/6 background were infected intraperitoneally with mouse hepatitis virus strain JHM (JHMV). In contrast to IFN-gamma-+/- and IFN-gamma+/+ mice, JHMV persisted in IFN-gamma-/- mice and induced death during the subacute phase of the infection. Unexpectedly, infected IFN-gamma-/- mice showed severe peritonitis accompanying the accumulation of a viscous fluid in the abdominal and thoracic cavities in the subacute phase. Destructive changes of hepatocytes were not observed. Administration of recombinant IFN-gamma protracted the survival time of IFN-gamma-/- mice after JHMV infection. These results demonstrate that IFN-gamma plays a critical role in viral clearance in JHMV infection. They also show that a resultant persistent JHMV infection induces another form of disease in IFN-gamma-/- mice, which bears a resemblance to feline infectious peritonitis in cats. |
