|  Help  |  About  |  Contact Us

Publication : The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development.

First Author  Tucker AS Year  2004
Journal  Dev Biol Volume  268
Issue  1 Pages  185-94
PubMed ID  15031115 Mgi Jnum  J:92196
Mgi Id  MGI:3051937 Doi  10.1016/j.ydbio.2003.12.019
Citation  Tucker AS, et al. (2004) The activation level of the TNF family receptor, Edar, determines cusp number and tooth number during tooth development. Dev Biol 268(1):185-94
abstractText  Mutations in members of the ectodysplasin (TNF-related) signalling pathway, EDA, EDAR, and EDARADD in mice and humans produce an ectodermal dysplasia phenotype that includes missing teeth and smaller teeth with reduced cusps. Using the keratin 14 promoter to target expression of an activated form of Edar in transgenic mice, we show that expression of this transgene is able to rescue the tooth phenotype in Tabby (Eda) and Sleek (Edar) mutant mice. High levels of expression of the transgene in wild-type mice result in molar teeth with extra cusps, and in some cases supernumerary teeth, the opposite of the mutant phenotype. The level of activation of Edar thus determines cusp number and tooth number during tooth development.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

5 Bio Entities

Trail: Publication

0 Expression