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Publication : Global ablation of the mouse Rab11a gene impairs early embryogenesis and matrix metalloproteinase secretion.

First Author  Yu S Year  2014
Journal  J Biol Chem Volume  289
Issue  46 Pages  32030-43
PubMed ID  25271168 Mgi Jnum  J:222158
Mgi Id  MGI:5644035 Doi  10.1074/jbc.M113.538223
Citation  Yu S, et al. (2014) Global ablation of the mouse Rab11a gene impairs early embryogenesis and matrix metalloproteinase secretion. J Biol Chem 289(46):32030-43
abstractText  Rab11a has been conceived as a prominent regulatory component of the recycling endosome, which acts as a nexus in the endo- and exocytotic networks. The precise in vivo role of Rab11a in mouse embryonic development is unknown. We globally ablated Rab11a and examined the phenotypic and molecular outcomes in Rab11a(null) blastocysts and mouse embryonic fibroblasts. Using multiple trafficking assays and complementation analyses, we determined, among multiple important membrane-associated and soluble cargos, the critical contribution of Rab11a vesicular traffic to the secretion of multiple soluble MMPs. Rab11a(null) embryos were able to properly form normal blastocysts but died at peri-implantation stages. Our data suggest that Rab11a critically controls mouse blastocyst development and soluble matrix metalloproteinase secretion.
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