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Publication : Fgf8-related secondary organizers exert different polarizing planar instructions along the mouse anterior neural tube.

First Author  Crespo-Enriquez I Year  2012
Journal  PLoS One Volume  7
Issue  7 Pages  e39977
PubMed ID  22792203 Mgi Jnum  J:189513
Mgi Id  MGI:5446062 Doi  10.1371/journal.pone.0039977
Citation  Crespo-Enriquez I, et al. (2012) Fgf8-related secondary organizers exert different polarizing planar instructions along the mouse anterior neural tube. PLoS One 7(7):e39977
abstractText  Early brain patterning depends on proper arrangement of positional information. This information is given by gradients of secreted signaling molecules (morphogens) detected by individual cells within the responding tissue, leading to specific fate decisions. Here we report that the morphogen FGF8 exerts initially a differential signal activity along the E9.5 mouse neural tube. We demonstrate that this polarizing activity codes by RAS-regulated ERK1/2 signaling and depends on the topographical location of the secondary organizers: the isthmic organizer (IsO) and the anterior neural ridge (anr) but not on zona limitans intrathalamica (zli). Our results suggest that Sprouty2, a negative modulator of RAS/ERK pathway, is important for regulating Fgf8 morphogenetic signal activity by controlling Fgf8-induced signaling pathways and positional information during early brain development.
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