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Publication : Pancreatic Pericytes Support β-Cell Function in a Tcf7l2-Dependent Manner.

First Author  Sakhneny L Year  2018
Journal  Diabetes Volume  67
Issue  3 Pages  437-447
PubMed ID  29246974 Mgi Jnum  J:258314
Mgi Id  MGI:6117908 Doi  10.2337/db17-0697
Citation  Sakhneny L, et al. (2018) Pancreatic Pericytes Support beta-Cell Function in a Tcf7l2-Dependent Manner. Diabetes 67(3):437-447
abstractText  Polymorphism in TCF7L2, a component of the canonical Wnt signaling pathway, has a strong association with beta-cell dysfunction and type 2 diabetes through a mechanism that has yet to be defined. beta-Cells rely on cells in their microenvironment, including pericytes, for their proper function. Here, we show that Tcf7l2 activity in pancreatic pericytes is required for beta-cell function. Transgenic mice in which Tcf7l2 was selectively inactivated in their pancreatic pericytes exhibited impaired glucose tolerance due to compromised beta-cell function and glucose-stimulated insulin secretion. Inactivation of pericytic Tcf7l2 was associated with impaired expression of genes required for beta-cell function and maturity in isolated islets. In addition, we identified Tcf7l2-dependent pericytic expression of secreted factors shown to promote beta-cell function, including bone morphogenetic protein 4 (BMP4). Finally, we show that exogenous BMP4 is sufficient to rescue the impaired glucose-stimulated insulin secretion of transgenic mice, pointing to a potential mechanism through which pericytic Tcf7l2 activity affects beta-cells. To conclude, we suggest that pancreatic pericytes produce secreted factors, including BMP4, in a Tcf7l2-dependent manner to support beta-cell function. Our findings thus propose a potential cellular mechanism through which abnormal TCF7L2 activity predisposes individuals to diabetes and implicates abnormalities in the islet microenvironment in this disease.
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