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Allele : Btk<tm1a(EUCOMM)Hmgu> Bruton agammaglobulinemia tyrosine kinase; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH

Primary Identifier  MGI:4434935 Allele Type  Targeted
Attribute String  Conditional ready, Null/knockout, Reporter Gene  Btk
Transmission  Germline Strain of Origin  C57BL/6N
Is Recombinase  false Is Wild Type  false
Project Collection  EUCOMM
molecularNote  The L1L2_Bact_P cassette was inserted at position 134559795 of Chromosome X upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 134558466. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
  • mutations:
  • Insertion
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0 Mutation Involves


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Trail: Allele