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Publication : Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells.

First Author  Montgomery RK Year  2011
Journal  Proc Natl Acad Sci U S A Volume  108
Issue  1 Pages  179-84
PubMed ID  21173232 Mgi Jnum  J:169012
Mgi Id  MGI:4939542 Doi  10.1073/pnas.1013004108
Citation  Montgomery RK, et al. (2011) Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A 108(1):179-84
abstractText  The intestinal epithelium is maintained by a population of rapidly cycling (Lgr5(+)) intestinal stem cells (ISCs). It has been postulated, however, that slowly cycling ISCs must also be present in the intestine to protect the genome from accumulating deleterious mutations and to allow for a response to tissue injury. Here, we identify a subpopulation of slowly cycling ISCs marked by mouse telomerase reverse transcriptase (mTert) expression that can give rise to Lgr5(+) cells. mTert-expressing cells distribute in a pattern along the crypt-villus axis similar to long-term label-retaining cells (LRCs) and are resistant to tissue injury. Lineage-tracing studies demonstrate that mTert(+) cells give rise to all differentiated intestinal cell types, persist long term, and contribute to the regenerative response following injury. Consistent with other highly regenerative tissues, our results demonstrate that a slowly cycling stem cell population exists within the intestine.
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