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Publication : Foxp3+ regulatory T cells maintain immune homeostasis in the skin.

First Author  Dudda JC Year  2008
Journal  J Exp Med Volume  205
Issue  7 Pages  1559-65
PubMed ID  18573908 Mgi Jnum  J:137389
Mgi Id  MGI:3799419 Doi  10.1084/jem.20072594
Citation  Dudda JC, et al. (2008) Foxp3+ regulatory T cells maintain immune homeostasis in the skin. J Exp Med 205(7):1559-65
abstractText  Cutaneous immune responses must be tightly controlled to prevent unwanted inflammation in response to innocuous antigens, while maintaining the ability to combat skin-tropic pathogens. Foxp3(+) regulatory T (T reg) cells are potent immune regulators and are found at high frequency in both human and mouse skin. Although T reg cells migrate to the skin and can dampen immune responses during experimentally induced inflammation or infection, the importance of cutaneous T reg cells for maintaining normal immune homeostasis in the skin has not been addressed. To selectively block T reg cell function in the skin, we restored the T reg cell compartment in Foxp3-deficient scurfy mice with cells whose ability to migrate to the skin was impaired because of targeted mutation of alpha-1,3-fucosyltransferase VII (Fut7). Although Fut7-deficient T reg cells were present at normal frequency and could function in all other tissues examined, these animals rapidly developed severe cutaneous inflammation. Thus, skin-resident T reg cell are essential for maintaining normal immune homeostasis at this site.
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