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Allele : Gt(ROSA)26Sor<tm1.1(DUX4*)Plj> gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Peter Jones

Primary Identifier  MGI:5707276 Allele Type  Targeted
Attribute String  Conditional ready, Humanized sequence, Inserted expressed sequence Gene  Gt(ROSA)26Sor
Transmission  Germline Strain of Origin  C57BL/6
Is Recombinase  false Is Wild Type  false
molecularNote  The targeting vector was designed with (from 5 to 3) a loxP site, an FRT-flanked neomycin resistance gene, a lox511 site, an inverted human double homeobox 4 (DUX4) gene with a polyadenylation sequence, and another loxP site and lox511 site, both in opposite orientation to the 5 sites. The DUX4 gene contains 4 silent point mutations in exon 1 that prevent alternative splicing of a truncated isoform, DUX4-s, while maintaining the DUX4-fl ORF. This entire construct was inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus. Flp-mediated recombination removed the FRT-flanked neo cassette.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • FLExDUX4,
  • FLExDUX4
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Human diseases

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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2 Carried By

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5 Publication categories

Trail: Allele