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Publication : Molecular and Genetic Evidence for the PDGFRα-Independent Population of Oligodendrocyte Progenitor Cells in the Developing Mouse Brain.

First Author  Zheng K Year  2018
Journal  J Neurosci Volume  38
Issue  44 Pages  9505-9513
PubMed ID  30242047 Mgi Jnum  J:266980
Mgi Id  MGI:6237473 Doi  10.1523/JNEUROSCI.1510-18.2018
Citation  Zheng K, et al. (2018) Molecular and Genetic Evidence for the PDGFRalpha-Independent Population of Oligodendrocyte Progenitor Cells in the Developing Mouse Brain. J Neurosci 38(44):9505-9513
abstractText  PDGFRalpha, specifically expressed by immature oligodendrocyte progenitor cells (OPCs) in the CNS, plays a critical role in OPC proliferation and migration. However, it has been uncertain whether all cells of oligodendrocyte lineage are derived from the PDGFRalpha-expressing OPCs. In the present study, we uncovered a PDGFRalpha-independent oligodendrocyte lineage in the developing cortex. This OPC subpopulation originates from the local ventricular/subventricular zone after birth and contributes to the earliest mature oligodendrocytes in the cortex. PDGFRalpha signaling does not regulate the generation and differentiation of cortical OPCs. Fate-mapping studies in the PDGFRalpha(CreER); Sox10-GFP/tdTom double-transgenic mice of either sex have further corroborated the PDGFRalpha-independent oligodendrocyte lineage. This study provides additional missing genetic evidence for PDGFRalpha-independent oligodendrocyte lineage in the developing hindbrain.SIGNIFICANCE STATEMENT This is the first report of a subpopulation of oligodendrocyte lineage in the developing mouse cortex independent of PDGFRalpha signaling. These oligodendrocyte progenitor cells are generated from the local ventral ventricular zone/subventricular zone after birth, and contribute to the earliest mature oligodendrocytes in the cortex.
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