| Type | MGI:General | Description | splenocytes harvested from homozygous mutant mice a week after their immunization with irradiated, ovallbumin- (OVA-) expressing C57BL/6 splenocytes and restimulated in vitro with an MHC class I-specific OVA peptide include no CD8+ IFNG+ cells recognizing the OVA peptide and exhibit no cytolytic activity against OVA peptide-bearing targets, demonstrating defective cross-presentation of antigen for MHC class I activation |
