| Type | MGI:General | Description | 4 weeks after transthoracic aorta constriction (TAC), mutants show a more pronounced increase in heart weight, a higher increase in lung weight/body weight, aggravated cardiac hypertrophy, a greater increase in cardiomyocyte cross-sectional area, in both both left ventricle end-systolic and end-diastolic diameters (LVESD and LVEDD), and cardiac fibrosis, and decreased LV ejection fraction and fractional shortening than wild-type mice |
