| Type | MGI:General | Description | carbamylcholine-induced contraction in gallbladder from (M4) homozygous mutant mice is dextrally shifted compared with the response in gallbladder from wild-type mice, but antagonism of carbamylcholine-induced contraction by AF-DX 116 or pirenzepine is not consistent with an interaction with M4 receptors, suggesting that gallbladder contractility to carbamylcholine is dependent on the presence of the M4 receptor for optimal efficacy |
