| Type | MGI:General | Description | homozygotes fail to exhibit a significant increase in locomotion in response to mixed D1/D2 dopaminergic agonists (apomorphine and SKF82958) or full D1 agonists (SKF81297), indicating significantly reduced postsynaptic responses to dopaminergic agonists and an inhibitory effect of the short isoform on D1R-mediated responses homozygotes fail to exhibit significant induction of catalepsy in response to haloperidol (a D2-like antagonist and antipsychotic drug), despite a normal haloperidol-induced increase of striatal dopamine levels in mutant mice; in contrast, SCH 23390 (a D1R antagonist) is still able to produce catalepsy in mutant mice |
