| Type | MGI:General | Description | in vitro analysis of inspiratory activity in mutant brain stem slices indicates prolonged periods of inactivity and a significantly reduced burst frequency with variable interburst intervals relative to the regular rhythmic bursting observed in control slices application of the glycine receptor antagonist strychnine (2 uM) increases burst activity by 3.6-fold leading to a frequency comparable to that seen under control conditions in wild-type mice; however, the activity of mutant slices is consistently more irregular than that of wild-type preparations the coefficient of variation of the interburst interval is significantly higher in mutant slices and is only partially improved upon strychnine application application of the GABAA receptor antagonist bicuculline (1-2 uM) fails to normalize the rhythmic burst patterns observed in mutant slices application of the NMDA receptor blockers MK-801 (10 uM) and AP-5 (100 uM) fails to restore a regular respiratory rhythm in mutant slices |
