| Type | MGI:General | Description | 7 days after secondary immunization with suboptimal dose of T cell-dependent antigen NP-KLH, number and size of germinal centers in mutant spleens are reduced compared to controls; number is reduced ~4fold, but numbers are normal in mice immunized with 10 or 100 ug of antigen germinal center reactions are also impaired when 1 ug of NP-KLH antigen is used for immunization |
