| Type | MGI:General | Description | 45 days after infection with Listeria monocytogenes expressing an immunodominant foreign, MHC class I (Kb)- restricted peptide, SIYRYYGL, mice have an 8-fold reduction in memory CD8 T cells and very few listeriolysin O-reactive memory CD4 T cells compared to in similarly treated wild-type mice re-challenging mice inoculated with Listeria monocytogenes expressing an immunodominant foreign, MHC class I (Kb)- restricted peptide, SIYRYYGL after 100 days increases the number of memory CD8+ T cells but levels are still lower than in similarly treated wild-type mice in mice inoculated with an H2-Kb MHC class I-IG fusion protein conjugated to PE loaded with SIY peptide, the number of memory CD8 T cells is reduced by 2.5-fold at day 60 and continues to decrease at day 100 unlike in similarly treated wild type mice |
