| Type | MGI:General | Description | mutant livers exhibit higher lactate content and specific activity of glycolytic enzymes (GAPDH and PK), suggesting enhanced glycolysis in culture, primary hepatocytes from mutant mice show significantly higher basal glycolytic rates and maximal glycolytic capacity and higher levels of glycolytic enzymes relative to control hepatocytes; basal and maximal glycolytic capacity remains significantly higher than in controls even 24 hr after removal of serum from the culture media after a 24 hr starvation, levels of different glycolytic enzymes in mutant livers remain higher than in control livers |
