| Type | MGI:General | Description | at E7.5 expression of Hex, a marker of anterior definitive endoderm, is often undetectable; however Hex expression in visceral endoderm is normal at E8.25 expression of Shh marking ventral midline structures and gut endoderm is greatly reduced or absent these changes in expression indicate defects in axial mesendoderm and definitive endoderm development with a nearly complete loss of definitive endoderm in severely affected embryos |
