| Type | MGI:General | Description | the proportion of pro-T cells is increased about 3-fold and fewer cells in transition between pre-T and late pre-T cell stages are found both pro-T and pre-T cells have increased CD25 expression about a 2-fold increase in apoptotic thymocytes is seen from E14 - E17 intrathymically injected bone marrow cells show extremely limited ability to reconstitute T cell development especially when in competition with heterozygous or wild-type cells most intrathymically injected cells arrest at the CD44+ CD25- double negativeprogenitor cell stage from E15 - E17, T cell maturation appears to be delayed by about 1 day compared to age-matched heterozygous littermates |
