| Type | MGI:General | Description | at P0, homozygotes show only a reduced density of afferent and efferent fibers to all vestibular sensory epithelia, with no specific loss of all afferent and efferent innervation to the canal crista; no increase in radial fiber spacing is noted in the apex at P7/P8, innervation is severely reduced both qualitatively and quantitatively despite a more severe loss of hair cells (1% in cochlea vs 20% in vestibular epithelia), the cochlea retains many more sensory neurons than vestibular epithelia (46% vs 15%) at 6 months, homozygotes show long term retention of cochlear sensory neurons, esp. in the cochlear apex retention of afferents and efferents is unrelated to hair cell differentiation, as not even immature hair cells are detectable at early postnatal stages in the cochlear apex |
