| Type | MGI:General | Description | starting at 3 weeks, mutant lungs exhibit progressive enlargement of alveolar macrophages, with multiple foci of large, foamy, alveolar macrophages observed by 6 weeks by 6-7 months, individual homozygotes exhibit a moderate to severe airspace enlargement, with focal areas of macrophage accumulation and perivascular/peribronchiolar monocytic infiltrates at 7 months, the parenchyma of mutant lungs shows increased elastin deposition, with short, thick, and more highly coiled elastic fibers than wild-type lungs |
