| Type | MGI:General | Description | refinement of the ipsilateral retinocollicular pathway and the contralateral retinogeniculate pathway of the retina to the superior colliculus and the dorsal lateral geniculate nucleus is abnormal in mutant mice at P15, the ipsilateral retinocollicular pathway was more robustly distributed than controls, with more extensive branching in the mediolateral axis of the superior colliculus and branches that extend into the dorsal superficial gray layer; at P21 and P28, refinement of the pathway occurs and is similar to adults by P28 at P15, the projections of the contralateral retinogeniculate pathway completely fills the contralateral dorsal lateral geniculate nucleus (dLGN) unlike controls, with little or no sign of the ipsilateral projections in the dLGN; these differences were less apparent at P21 and P28 |
