| Type | MGI:General | Description | at day 8 after oral administration of 2.5% dextran sulfate sodium (DSS), heterozygotes show accelerated weight loss, increased histopathological severity scores (based on severity of inflammation, depth of inflammation and crypt damage), decreased colon length, reduced epithelial proliferation in response to injury, and a marked inflammatory gene expression signature in colonic tissue relative to wild-type controls |
