| Type | MGI:General | Description | defective presentation of self-antigens to class I-restricted cytotoxic T lymphocytes (CTLs) is observed in null-cells; defects in reactivity of two H60-specific CTL clones and an HY-specific clone with null cells is seen, while H4b-specific clones react similarly with null splenocytes and wild-type cells, and an H13b-specific clone reacted with null cells more strongly than with wild-type a panel of Qa-1b-restricted, alloreactive CTL clones each show a significant reduction in capacity to lyse mutant splenic cells compared with wild-type cells when ovalbumin is introduced to cell cytoplasm by osmotic shock, mutant cells show impairment in presentation of OVA-derived epitopes; bone marrow-derived dendritic cells and LPS-induced lymphoblasts are also defective in presenting OVA to a an OVA-specific H-2Kb-restricted T cell hybridoma mutant macrophages infected with OVA-expressing bacteria are defective in antigen presentation to OVA specific T cells dendritic cells infected with LCMV show enhanced reactivity with gp33 (immunodominant LCMV-derived epitope)-T cells compared to wild-type cells |
