| Type | MGI:General | Description | ~50% of islets are infiltrated to various degrees with small nucleated cells; most cells are naive B220+ B cells; pancreata contain high numbers of lymphocytes, with an enrichment in B lyphocytes compared to peripheral blood B cells are localized adjacent to pancreatic beta cells while CD3+ T cells are localized more distantly CD4 and CD8 T cells (showing low levels of acute activation) are also present in higher numbers than nontransgenic controls islet architecture is frequently disturbed, resembling severe insulitis, but beta cell loss or diabetes is not seen small infiltrates (>30 cells/section) are composed mainly of B cells, while medium-sized infiltrates (30-300 cells) have an increased number of B cells, T cells and DCs (dendritic cells) and HEVs and large-sized infiltrates (>~300 cells) have well defined T and B cell-rich zones |
