| Type | MGI:General | Description | prominent cytoplasmic and nuclear inclusions immunoreactive to human alpha-synuclein are observed by 2 months of age; these are most frequent in neurons of the deep neocortex, CA3 region of the hippocampus, olfactory bulb and occasionally the substantia nigra in 9-11 month old mice, larger inclusions composed of fine granular material are seen, and contain clear vacuoles |
