| Type | MGI:General | Description | mice show reduced mitochondrial respiratory complex I respiratory rates: ATP-producing state III respiration is diminished by 32% in cortical and 36% in hippocampal mitochondria and the maximal rate of the electron transport (state V) is reduced in both cortical and hippocampal mitochondria, indicating that mitochondria consume less oxygen UCP2 protein levels are reduced by 20% in mitochondria and functional uncoupling is reduced by 68%, indicating a loss of function of the protein machinery that promotes successful electron transport mice treated with AATP show improved mitochondrial functions |
