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Type  MGI:General Description  observed in 100% of mice neural folds "mushroom" outward and do not converge at the dorsal midline by E10.25 the neural tube is malformed along the anterior-posterior axis resulting in the exposure of the forebrain neuroepithelium 23% of fetuses exhibited failed caudal neural tube closure resulting in spina bifida surrounding tissues, including the notochord, floor plate, head mesenchyme, and somites, appear normal