| Type | MGI:General | Description | in response to chronic hypoxia (10% oxygen for 1 day to 3 wk), male homozygotes display a 30% reduction in cardiac systolic function; no changes in heart rate are observed relative to wild-type mice this degree of hypoxia-induced LV systolic dysfunction remains constant, regardless of the period of hypoxic exposure (1?3 wk) hypoxia-induced cardiac dysfunction is reversible upon reexposure to normoxic conditions (21% O2) and can be prevented with treatment of an inhibitor of nitric oxide (NO) synthases |
