| Type | MGI:General | Description | action potential shapes measured by whole cell patch clamp recordings of 5-HT neurons in the DRN indicate that no differences is seen in the amplitude or duration of action potential or in the amplitude of after hyperpolarization between mutant and control neurons; however, when the membrane potential is depolarized by intracellular current injection, these neurons fire more frequently in the mutant mice than in the controls application of bicuculline, a GABAA receptor antagonist to 5-HT neurons in the DRN increases the firing rates in both mutant and control mice, but a significant increase remains in the magnitude of the firing rate in mutant compared to control mice |
